Krishnamurthy S, Bharadwaj R
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India.
Acta Cytol. 1998 Nov-Dec;42(6):1444-6. doi: 10.1159/000332183.
Fine needle aspiration cytology is an established method for cytodiagnosis. Its application is particularly suited to the pediatric age group. A correct cytodiagnosis of especially large tumors can result in timely cytoreductive chemotherapy, thereby facilitating surgery. While the cytomorphology of Wilms' tumor is well documented, there is a paucity of literature concerning other uncommon pediatric renal tumors.
A 2-year-old female underwent surgery for a renal mass following aspiration cytology. The histologic diagnosis was clear cell sarcoma of the kidney (CCSK). The cytologic smears were cellular and pleomorphic. The main feature of cytologic interest was the presence of deep nuclear indentations and grooves in many of the tumor cells.
The cytologic features of CCSK are distinct and different from those of other renal tumors in children. Its recognition in cytology is important because its behavior is more aggressive than that of Wilms' tumor. A correct diagnosis can result in the institution of appropriate treatment.
细针穿刺细胞学检查是一种成熟的细胞诊断方法。它的应用特别适用于儿童年龄组。对尤其是大型肿瘤进行正确的细胞诊断可导致及时进行细胞减灭化疗,从而便于手术。虽然肾母细胞瘤的细胞形态学已有充分记录,但关于其他罕见儿童肾肿瘤的文献却很少。
一名2岁女性在细针穿刺细胞学检查后接受了肾脏肿块手术。组织学诊断为肾透明细胞肉瘤(CCSK)。细胞学涂片细胞丰富且多形性。细胞学上主要感兴趣的特征是许多肿瘤细胞中存在深核凹陷和沟。
CCSK的细胞学特征与儿童其他肾肿瘤不同。在细胞学中识别它很重要,因为其行为比肾母细胞瘤更具侵袭性。正确的诊断可导致采取适当的治疗措施。