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1
Occurrence of squalene in methanol-grown bacteria.角鲨烯在甲醇培养细菌中的出现情况。
J Bacteriol. 1978 Aug;135(2):717-20. doi: 10.1128/jb.135.2.717-720.1978.
2
Maintenance requirements for bacteria growing on C1-compounds.在C1化合物上生长的细菌的营养需求。
Biotechnol Bioeng. 1978 Oct;20(10):1557-64. doi: 10.1002/bit.260201005.
3
Carbon isotopic fractionation in lipids from methanotrophic bacteria: relevance for interpretation of the geochemical record of biomarkers.甲烷氧化菌脂质中的碳同位素分馏：对生物标志物地球化学记录解释的相关性。
Geochim Cosmochim Acta. 1994;58(13):2853-63. doi: 10.1016/0016-7037(94)90119-8.
4
Bacterial yields on methanol, methylamine, formaldehyde, and formate.甲醇、甲胺、甲醛和甲酸盐上的细菌产量。
Biotechnol Bioeng. 1976 Dec;18(12):1657-68. doi: 10.1002/bit.260181202.
5
Electron microscopy of methanol-utilizing bacteria.利用甲醇的细菌的电子显微镜检查
Antonie Van Leeuwenhoek. 1978;44(2):123-7. doi: 10.1007/BF00643215.
6
Fluorescent pigments in the newly isolated methylotrophs: Pseudomonas J16 and Methylomonas Pl1.新分离的甲基营养菌中的荧光色素：假单胞菌J16和甲基单胞菌Pl1。
Acta Microbiol Pol. 1978;27(3):257-67.
7
[Action of polycarbon compounds on the oxidation of methanol and other Cl compounds by methylotrophic bacteria].[聚碳酸化合物对甲基营养菌氧化甲醇及其他含氯化合物的作用]
Nauchnye Doki Vyss Shkoly Biol Nauki. 1983(6):83-7.
8
Oxidation of methanol by facultative and obligate methylotrophs.兼性和专性甲基营养菌对甲醇的氧化作用。
Acta Biochim Pol. 1976;23(4):375-86.
9
A comparative transcriptome analysis of the novel obligate methanotroph Methylomonas sp. DH-1 reveals key differences in transcriptional responses in C1 and secondary metabolite pathways during growth on methane and methanol.新型专性甲烷营养菌 Methylomonas sp. DH-1 的比较转录组分析揭示了其在甲烷和甲醇生长过程中 C1 转录响应和次生代谢途径的关键差异。
BMC Genomics. 2019 Feb 12;20(1):130. doi: 10.1186/s12864-019-5487-6.
10
Growth of Pseudomonas C on C1 compounds: enzyme activites in extracts of Pseudomonas C cells grown on methanol, formaldehyde, and formate as sole carbon sources.铜绿假单胞菌在C1化合物上的生长：以甲醇、甲醛和甲酸盐作为唯一碳源生长的铜绿假单胞菌细胞提取物中的酶活性
J Bacteriol. 1975 Apr;122(1):47-53. doi: 10.1128/jb.122.1.47-53.1975.

引用本文的文献

1
Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry - A Review.微生物角鲨烯：化妆品和制药行业的可持续替代方案——综述
Eng Life Sci. 2024 Aug 27;24(10):e202400003. doi: 10.1002/elsc.202400003. eCollection 2024 Oct.
2
From Sharks to Yeasts: Squalene in the Development of Vaccine Adjuvants.从鲨鱼到酵母：角鲨烯在疫苗佐剂研发中的应用
Pharmaceuticals (Basel). 2022 Feb 22;15(3):265. doi: 10.3390/ph15030265.
3
Engineering Strategies in Microorganisms for the Enhanced Production of Squalene: Advances, Challenges and Opportunities.用于提高角鲨烯产量的微生物工程策略：进展、挑战与机遇
Front Bioeng Biotechnol. 2019 Mar 22;7:50. doi: 10.3389/fbioe.2019.00050. eCollection 2019.
4
Chemiosmotic coupling in Methanobacterium thermoautotrophicum: hydrogen-dependent adenosine 5'-triphosphate synthesis by subcellular particles.嗜热自养甲烷杆菌中的化学渗透偶联：亚细胞颗粒依赖氢气合成腺苷 5'-三磷酸
J Bacteriol. 1979 Dec;140(3):1081-9. doi: 10.1128/jb.140.3.1081-1089.1979.

本文引用的文献

1
On the mechanism of enzymatic cyclization of squalene.关于角鲨烯的酶促环化机制。
J Biol Chem. 1957 Jun;226(2):931-9.
2
[Cholesterol in Streptomyces olivaceus].[橄榄色链霉菌中的胆固醇]
Biochim Biophys Acta. 1967 Feb 14;137(1):168-71.
3
Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrun.在极端嗜盐细菌——深红嗜盐杆菌中鲨烯、二氢鲨烯和四氢鲨烯以及维生素MK8的存在情况。
J Lipid Res. 1969 May;10(3):294-303.
4
Occurrence of dehydrosqualene (C30 phytoene) in Staphylococcus aureus.脱氢鲨烯（C30 八氢番茄红素）在金黄色葡萄球菌中的出现情况。
Biochim Biophys Acta. 1968 Sep 2;164(1):88-93. doi: 10.1016/0005-2760(68)90074-x.
5
Sterols: isolation from a blue-green alga.甾醇：从一种蓝绿藻中分离得到
Science. 1968 Oct 18;162(3851):363. doi: 10.1126/science.162.3851.363.
6
The isolation and identification of two sterols from two species of blue-green algae.
Comp Biochem Physiol. 1968 May;25(2):401-16. doi: 10.1016/0010-406x(68)90349-6.
7
Presence of squalene in Staphylococcus.
Arch Biochem Biophys. 1968 Mar 11;123(3):644. doi: 10.1016/0003-9861(68)90187-2.
8
Some properties of the microsomal 2,3-oxidosqualene sterol cyclase.微粒体2,3-氧化角鲨烯甾醇环化酶的一些特性。
Proc Natl Acad Sci U S A. 1969 May;63(1):110-7. doi: 10.1073/pnas.63.1.110.
9
Isolation and identification of dehydrosqualene and C 40 -carotenoid pigments in Halobacterium cutirubrum.深红嗜盐菌中脱氢鲨烯和C40 -类胡萝卜素色素的分离与鉴定。
Biochim Biophys Acta. 1972 Mar 23;260(3):492-506. doi: 10.1016/0005-2760(72)90064-1.
10
Structure ditermination of the squalene, dihydrosqualene and tetrahydrosqualene in Halobacterium cutirubrum.红皮盐杆菌中鲨烯、二氢鲨烯和四氢鲨烯的结构测定
Biochim Biophys Acta. 1972 May 23;270(1):103-10. doi: 10.1016/0005-2760(72)90183-x.

角鲨烯在甲醇培养细菌中的出现情况。

Occurrence of squalene in methanol-grown bacteria.

作者信息

Goldberg I, Shechter I

出版信息

J Bacteriol. 1978 Aug;135(2):717-20. doi: 10.1128/jb.135.2.717-720.1978.

DOI:10.1128/jb.135.2.717-720.1978
PMID:98521
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC222434/
Abstract

The nonpolar lipids of methanol-grown bacteria which utilize one-carbon (C1) compounds via the RMP pathway (Pseudomonas C, Pseudomonas methylotropha, and Methylomonas methanolica) were found to contain squalene in concentrations between 0.1 to 1.16 mg/g of cell (dry weight). Squalene could not be detected in lipid extracts of methanol-grown bacteria which utilize C1 compounds via the serine pathway.

摘要

通过核糖单磷酸途径（RMP途径）利用一碳（C1）化合物的甲醇生长细菌（假单胞菌C、甲基营养假单胞菌和甲醇甲基单胞菌）的非极性脂质，被发现含有浓度在0.1至1.16毫克/克细胞（干重）之间的角鲨烯。在通过丝氨酸途径利用C1化合物的甲醇生长细菌的脂质提取物中未检测到角鲨烯。