Iorio A M, Alatri A, Camilloni B, Neri M, Baglio G, Donatelli I
Department of Hygiene, University of Perugia, Italy.
Gerontology. 1999 Jan-Feb;45(1):31-8. doi: 10.1159/000022052.
Concern about poor responsiveness to influenza vaccination by institutionalized elderly people.
To determine whether institutionalized elderly volunteers develop a significant antibody response following influenza vaccine and to compare this response with that of non-institutionalized subjects.
The haemagglutination-inhibiting antibody response after 1995-1996 influenza vaccination [A/Shangdong/9/93 (H3N2), A/Taiwan/1/86 (H1N1), B/Panama/45/90] was estimated in 80 elderly women living in a nursing home and compared with that of 51 non-institutionalized women.
No differences were found in the prevaccination status, and, after vaccination, a significant humoral response was elicited both in institutionalized and non-institutionalized elderly subjects against all three influenza strains tested. The immune response of institutionalized patients was satisfactory and significantly higher than that observed in non-institutionalized women. These results were confirmed both by a separate analysis of homogeneous subgroups stratified according to the presence in the two cohorts of potential causes of differential antibody response (prevaccination antibody titre, age, long-term drug treatment, risk factors for influenza infection, and physical disability) and by logistic regression analysis in order to adjust immune responses for the different variables.
Influenza vaccination is effective in elderly people living in nursing homes. However, the postvaccination antibody response to influenza vaccine is influenced by different factors directly or indirectly related to residence.
对机构养老的老年人流感疫苗接种反应不佳表示担忧。
确定机构养老的老年志愿者接种流感疫苗后是否产生显著的抗体反应，并将这种反应与非机构养老的受试者进行比较。
对居住在养老院的80名老年女性接种1995 - 1996年流感疫苗[A/山东/9/93（H3N2）、A/台湾/1/86（H1N1）、B/巴拿马/45/90]后的血凝抑制抗体反应进行评估，并与51名非机构养老的女性进行比较。
接种疫苗前的状况未发现差异，接种疫苗后，机构养老和非机构养老的老年受试者对所有三种测试流感毒株均产生了显著的体液反应。机构养老患者的免疫反应令人满意，且显著高于非机构养老女性。通过根据两组中可能导致抗体反应差异的原因（接种疫苗前抗体滴度、年龄、长期药物治疗、流感感染风险因素和身体残疾）对同质亚组进行单独分析，以及通过逻辑回归分析以针对不同变量调整免疫反应，均证实了这些结果。
流感疫苗接种对居住在养老院的老年人有效。然而，接种疫苗后对流感疫苗的抗体反应受与居住直接或间接相关的不同因素影响。
