Hara Megumi, Tanaka Keitaro, Kase Tetsuo, Maeda Akiko, Hirota Yoshio
Department of Preventive Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan.
Vaccine. 2010 Aug 9;28(35):5664-8. doi: 10.1016/j.vaccine.2010.06.061.
Influenza vaccination efficacy was evaluated in 114 institutionalized elderly people in 2002/03. Strain A/H3N2 was isolated; 44 and 8 subjects had sudden-onset fever (> or = 37.8 degrees C) and kit-diagnosed influenza, respectively. Odds ratios adjusted for age, sex, comorbidity, and vaccine strain (OR(adj)) were determined using multiple logistic regression. Seroprotected patients (haemagglutination-inhibition antibody titre > or = 1:40) had lower incidence of fever (OR(adj), 0.35; 95% confidence interval [CI], 0.09-1.28) and kit-diagnosed influenza (OR(adj), 0.35; 95% CI, 0.03-4.64) than patients without seroprotection (antibody efficacy, approximately 65%). Seroprotective levels of vaccination-induced antibodies probably prevent influenza among the institutionalized elderly, although statistical significance could not be confirmed owing to the sample size.
2002/03年，在114名入住养老院的老年人中评估了流感疫苗的效力。分离出了A/H3N2毒株；分别有44名和8名受试者突然发烧（体温≥37.8摄氏度）且试剂盒诊断为流感。使用多因素逻辑回归确定经年龄、性别、合并症和疫苗毒株调整后的优势比（OR(adj)）。血清保护的患者（血凝抑制抗体滴度≥1:40）发烧（OR(adj)，0.35；95%置信区间[CI]，0.09 - 1.28）和试剂盒诊断为流感（OR(adj)，0.35；95% CI，0.03 - 4.64）的发生率低于无血清保护的患者（抗体效力约为65%）。疫苗诱导抗体的血清保护水平可能预防入住养老院老年人中的流感，尽管由于样本量的原因无法确认统计学显著性。
