Anlar B, Yalaz K, Köse G, Saygi S
Hacettepe University Department of Pediatric Neurology, Ankara, Turkey.
J Child Neurol. 1998 Nov;13(11):557-9. doi: 10.1177/088307389801301106.
We treated seven patients with subacute sclerosing panencephalitis with beta-interferon and oral inosiplex for 2 to 15 months. Stabilization or improvement was observed in three patients. The effect of treatment was equivocal in two other patients who became stable. The disease continued its progression in the remaining two patients who died. Treatment shorter than 2 months was not effective. Changes in electroencephalograms (EEG), magnetic resonance images (MRI), or cerebrospinal fluid measles antibody levels did not have a close correlation with clinical course. These results suggest that beta-interferon might be efficient in some patients with subacute sclerosing panencephalitis and justify its trial in larger studies with longer follow-up.
我们用β-干扰素和口服肌苷片治疗了7例亚急性硬化性全脑炎患者，治疗时间为2至15个月。3例患者病情稳定或有所改善。另外2例病情稳定的患者治疗效果不明确。其余2例患者病情继续进展并死亡。治疗时间短于2个月无效。脑电图（EEG）、磁共振成像（MRI）或脑脊液麻疹抗体水平的变化与临床病程无密切相关性。这些结果表明，β-干扰素可能对某些亚急性硬化性全脑炎患者有效，有理由在更长随访期的更大规模研究中进行试验。
