Anand S S, Yusuf S, Vuksan V, Devanesen S, Montague P, Kelemen L, Bosch J, Sigouin C, Teo K K, Lonn E, Gerstein H C, Hegele R A, McQueen M
Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario.
Can J Cardiol. 1998 Nov;14(11):1349-57.
The Study of Health Assessment and Risk in Ethnic groups (SHARE) is a study to determine the risk factors for atherosclerosis among three ethnic populations in Canada. Three hundred and thirty South Asian Canadian, 320 Chinese Canadian and 320 European Canadian men and women between 35 and 75 years of age are being randomly sampled from communities in Hamilton and Toronto, Ontario and Edmonton, Alberta for assessment of conventional (i.e., smoking, dyslipidemia, diabetes and hypertension) and emerging (i.e., candidate genes for atherosclerosis, homocysteine, fibrinolytic parameters, neurohormones, glucose intolerance, markers of infection, socioeconomic status, psychosocial status and diet) cardiovascular disease risk factors. Subclinical atherosclerosis is measured by quantitative B-mode ultrasonography of the carotid arteries, and other objective measures of vascular disease are a 12-lead electrocardiogram, a two-dimensional echocardiogram, ankle to arm blood pressure ratio and urine microalbumin concentration. The relationship between the conventional and emerging risk factors, and atherosclerosis, vascular disease and markers of end-organ damage will be evaluated between and within ethnic groups.
族群健康评估与风险研究（SHARE）是一项旨在确定加拿大三个族裔人群动脉粥样硬化风险因素的研究。从安大略省汉密尔顿市和多伦多市以及阿尔伯塔省埃德蒙顿市的社区中，随机抽取330名南亚裔加拿大居民、320名华裔加拿大居民以及320名欧裔加拿大居民，年龄在35至75岁之间，以评估传统（即吸烟、血脂异常、糖尿病和高血压）和新出现的（即动脉粥样硬化候选基因、同型半胱氨酸、纤溶参数、神经激素、葡萄糖耐量异常、感染标志物、社会经济地位、心理社会状况和饮食）心血管疾病风险因素。通过颈动脉定量B型超声检查来测量亚临床动脉粥样硬化，血管疾病的其他客观测量指标包括12导联心电图、二维超声心动图、踝臂血压比值和尿微量白蛋白浓度。将在族裔群体之间以及群体内部评估传统和新出现的风险因素与动脉粥样硬化、血管疾病以及终末器官损害标志物之间的关系。
