Anand S S, Yusuf S
Department of Preventive Cardiology and Therapeutics, Hamilton Civic Hospitals Research Centre, McMaster University, Ont.
Clin Invest Med. 1997 Aug;20(4):204-10.
To test the feasibility of recruitment strategies and a 2-hour cardiovascular (CV) health assessment (including laboratory tests and questionnaires) in preparation for a national, population-based study to determine CV risk factors among Canadians of different ethnic origins.
Cross-sectional study of people of South Asian and European origin from Hamilton, Ont., identified by community-based stratified random sampling.
University-affiliated research clinic in Hamilton, Ont.
Thirty-one Canadians of South Asian origin and 20 Canadians of European origin 35 to 75 years of age.
Subjects attended a clinic at which they completed a health questionnaire, provided fasting and postprandial blood samples, and underwent B-mode carotid ultrasonographic examination as well as anthropometric, nutritional and psychosocial assessments.
The participants of South Asian origin had lived in Canada for 18 years, on average, compared with 48 years for those of European origin. More participants of South Asian origin were married than those of European origin, and fewer smoked or consumed alcohol. Participants of South Asian origin were more likely to have some university education. The prevalence of impaired glucose tolerance was 34.5% in the participants of South Asian origin and 9.5% in those of European origin (p < 0.04). The total cholesterol to high-density lipoprotein ratio was elevated in the participants of South Asian origin (5.1), compared with those of European origin (4.2) (p < 0.05), as was the lipoprotein (a) concentration (log transformed) (5.5 v. 4.6 mg/dL, p < 0.02).
This pilot study revealed intriguing lifestyle and metabolic differences between participants of South Asian and European origin. Those of South Asian origin had a higher prevalence of impaired glucose tolerance, dyslipidemia and elevated lipoprotein (a) concentrations-factors thought to be associated with premature CVD in this group.
为一项基于全国人口的研究做准备，该研究旨在确定不同种族背景的加拿大人的心血管风险因素，测试招募策略和两小时心血管健康评估（包括实验室检查和问卷调查）的可行性。
通过基于社区的分层随机抽样，对安大略省汉密尔顿市的南亚裔和欧洲裔人群进行横断面研究。
安大略省汉密尔顿市的大学附属研究诊所。
31名年龄在35至75岁之间的南亚裔加拿大人和20名欧洲裔加拿大人。
受试者前往诊所，在那里他们完成了一份健康问卷，提供了空腹和餐后血样，并接受了B型颈动脉超声检查以及人体测量、营养和社会心理评估。
南亚裔参与者平均在加拿大生活了18年，而欧洲裔参与者为48年。南亚裔参与者中已婚的比欧洲裔更多，吸烟或饮酒的更少。南亚裔参与者接受过大学教育的可能性更大。南亚裔参与者中糖耐量受损的患病率为34.5%，欧洲裔为9.5%（p<0.04）。南亚裔参与者的总胆固醇与高密度脂蛋白之比（5.1）高于欧洲裔参与者（4.2）（p<0.05），脂蛋白（a）浓度（对数转换后）也是如此（5.5对4.6mg/dL，p<0.02）。
这项试点研究揭示了南亚裔和欧洲裔参与者在生活方式和代谢方面存在有趣的差异。南亚裔参与者糖耐量受损、血脂异常和脂蛋白（a）浓度升高的患病率更高，这些因素被认为与该群体的心血管疾病早发有关。
