己烯雌酚在体外经大鼠肝微粒体组分及在培养的小鼠胎儿细胞中与脱氧核糖核酸的结合
Binding of diethylstilboestrol to deoxyribonucleic acid by rat liver microsomal fractions in vitro and in mouse foetal cells in culture.
作者信息
Blackburn G M, Thompson M H, King H W
出版信息
Biochem J. 1976 Sep 15;158(3):643-6. doi: 10.1042/bj1580643.
Abstract
Diethylstillboestrol, a synthetic and carcinogenic hormone, binds to DNA as a result of incubation with a liver microsomal preparation in vitro and on incubation with primary mouse foetal cells in culture. Enzymic digestion of DNA samples thus prepared gives several covalent deoxyribonucleoside-diethylstilboestrol products from the microsomal system. One of these is produced in small but significant yield in the tissue-culture system.
摘要
己烯雌酚是一种合成的致癌激素，在体外与肝微粒体制剂一起孵育以及与培养的原代小鼠胎儿细胞一起孵育时会与DNA结合。由此制备的DNA样品经酶消化后，从微粒体系统中得到了几种共价脱氧核糖核苷 - 己烯雌酚产物。其中一种在组织培养系统中产量虽小但具有显著意义。
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Binding of diethylstilboestrol to deoxyribonucleic acid by rat liver microsomal fractions in vitro and in mouse foetal cells in culture.己烯雌酚在体外经大鼠肝微粒体组分及在培养的小鼠胎儿细胞中与脱氧核糖核酸的结合
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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