Shively C A
Department of Pathology (Comparative Medicine), Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.
Psychoneuroendocrinology. 1998 Oct;23(7):713-32. doi: 10.1016/s0306-4530(98)00039-0.
The effects of contraceptive steroids and estrogen replacement therapy on behavior and neuroendocrine function were evaluated in adult female cynomolgus monkeys. During the 'premenopausal' phase of the experiment, the animals were assigned to either treatment with a triphasic oral contraceptive (OC) for 24 months or the untreated control group. The monkeys were then ovariectomized and half of each of the premenopausal groups were randomly assigned to either treatment with conjugated equine estrogens (ERT) or the untreated control group for 12 months (the 'postmenopausal' phase). All evaluations were completed during the postmenopausal phase of the experiment. Both types of exogenous steroid treatments appeared to increase cardiovascular and hypothalamic-pituitary-adrenal responses to stress in socially dominant but not socially subordinate females. A history of triphasic OC administration increased contact aggression received, and reduced the prolactin response to fenfluramine, suggesting reduced serotonergic activity, for at least a year following the cessation of triphasic OC treatment.
在成年雌性食蟹猴中评估了避孕类固醇和雌激素替代疗法对行为和神经内分泌功能的影响。在实验的“绝经前”阶段，将动物分为接受三相口服避孕药（OC）治疗24个月的组或未治疗的对照组。然后对猴子进行卵巢切除术，绝经前每组中的一半被随机分配接受结合马雌激素（ERT）治疗或未治疗的对照组，为期12个月（“绝经后”阶段）。所有评估均在实验的绝经后阶段完成。两种类型的外源性类固醇治疗似乎都增加了处于社会优势地位而非社会从属地位的雌性对压力的心血管和下丘脑-垂体-肾上腺反应。三相OC给药史增加了所接受的接触性攻击行为，并降低了对芬氟拉明的催乳素反应，这表明在三相OC治疗停止后至少一年内血清素能活性降低。
