Krogsgaard M R, Wagn P, Bengtsson J
Department of Orthopaedic Surgery M, Bispebjerg Hospital, Copenhagen NV, Denmark.
Acta Orthop Scand. 1998 Oct;69(5):513-7. doi: 10.3109/17453679808997789.
We studied the epidemiology of acute, non-tuberculous, hematogenous vertebral osteomyelitis in Denmark during 1978-1982. 137 patients fulfilled the criteria for acute vertebral osteomyelitis. The incidence was 5/mill/year. There were no cases in the age group 20-29 years. The highest incidence was between 60-69 years (18/mill/year). The prevalence was 15 cases. The mean duration of the disease was 7 months. The lumbar spine was affected in 59%, the thoracic spine in 33% and the cervical spine in 8% of the cases. Insulin-dependent diabetes and treatment with systemic corticosteroids seemed to be significant risk factors, but not rheumatoid arthritis and abuse of alcohol or intravenous drugs. We found no demographic variables of importance for the incidence. In 46%, a primary focus was identified, urinary tract infection being the commonest. According to the National Patient Register 1991-1993, the relative number of reported patients with vertebral osteomyelitis had increased in the age group 20-49 years, compared to 1978-1982, but the incidence was highest in the group aged 60-79 years.
我们研究了1978年至1982年丹麦急性、非结核性血源性椎体骨髓炎的流行病学情况。137例患者符合急性椎体骨髓炎的标准。发病率为每年5/百万。20至29岁年龄组无病例。发病率最高的是60至69岁年龄组（每年18/百万）。患病率为15例。疾病的平均持续时间为7个月。59%的病例腰椎受累，33%的病例胸椎受累，8%的病例颈椎受累。胰岛素依赖型糖尿病和全身使用皮质类固醇治疗似乎是重要的危险因素，但类风湿关节炎、酗酒或滥用静脉注射药物不是。我们未发现对发病率有重要影响的人口统计学变量。46%的病例确定了原发灶，其中尿路感染最为常见。根据1991年至1993年的国家患者登记数据，与1978年至1982年相比，20至49岁年龄组报告的椎体骨髓炎患者相对数量有所增加，但发病率最高的是60至79岁年龄组。
