伴有t(3;22)(q27;q11)的儿童原发性骨弥漫大B细胞淋巴瘤
Pediatric primary diffuse large cell lymphoma of bone with t(3;22)(q27;q11).
作者信息
Antillon F, Behm F G, Raimondi S C, Kaste S C, Sandlund J T, Pappo A S
机构信息
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
出版信息
J Pediatr Hematol Oncol. 1998 Nov-Dec;20(6):552-5.
PURPOSE
A child with a primary lymphoma of bone (PLB) with a t(3;22)(q27;q11) is described.
METHODS
An 11-year-old boy had a 5-week history of back pain and a destructive lesion of S1 that contained an epidural component. Histologic evaluation of a biopsy confirmed the diagnosis of diffuse large B-cell non-Hodgkin lymphoma. Karyotypic analysis disclosed a t(3;22)(q27;q11), but the amount of tumor tissue was insufficient for molecular studies of the BCL-6 gene.
RESULTS
The patient remains free of disease 4 years after completion of intensive systemic chemotherapy and intrathecal chemotherapy.
CONCLUSIONS
The lymphoma in the patient described in this report is highly unusual because of the coexistence of pediatric PLB and a t(3;22)(q27q11).
目的
描述一名患有原发性骨淋巴瘤（PLB）且伴有t(3;22)(q27;q11)的儿童。
方法
一名11岁男孩有5周的背痛病史，S1椎体有一个包含硬膜外成分的破坏性病变。活检的组织学评估证实为弥漫性大B细胞非霍奇金淋巴瘤。核型分析显示存在t(3;22)(q27;q11)，但肿瘤组织量不足以进行BCL-6基因的分子研究。
结果
在完成强化全身化疗和鞘内化疗4年后，该患者仍无疾病。
结论
本报告中描述的患者的淋巴瘤非常罕见，因为同时存在儿童PLB和t(3;22)(q27q11)。
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