Lee S, McAuliffe D J, Flotte T J, Kollias N, Doukas A G
Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, Boston 02114, USA.
J Invest Dermatol. 1998 Dec;111(6):925-9. doi: 10.1046/j.1523-1747.1998.00415.x.
Transcutaneous drug delivery has been the subject of intensive research. In certain situations, rapid transcutaneous delivery is very desirable. A mechanical (stress) pulse generated by a single laser pulse was shown to transiently increase the permeability of the stratum corneum in vivo. The barrier function of the stratum corneum recovers within minutes. The increased permeability during these few minutes allows macromolecules to diffuse through the stratum corneum into the viable epidermis and dermis. Macromolecules (40 kDa dextran and 20 nm latex particles) were deposited into the skin using a photomechanical pulse generated by a single 23 ns laser pulse. This treatment can potentially be utilized in therapies that currently require occlusive dressings for hours or day(s).
经皮给药一直是深入研究的主题。在某些情况下，快速经皮给药是非常可取的。由单个激光脉冲产生的机械（应力）脉冲已被证明可在体内短暂增加角质层的通透性。角质层的屏障功能在几分钟内即可恢复。在这几分钟内增加的通透性使大分子能够通过角质层扩散到有活力的表皮和真皮中。使用单个23纳秒激光脉冲产生的光机械脉冲将大分子（40 kDa葡聚糖和20纳米乳胶颗粒）沉积到皮肤中。这种治疗方法有可能应用于目前需要数小时或数天封闭敷料的治疗中。
