Mezey E, Dehejia A M, Harta G, Tresser N, Suchy S F, Nussbaum R L, Brownstein M J, Polymeropoulos M H
Basic Neuroscience Program, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD 20892-1430, USA.
Mol Psychiatry. 1998 Nov;3(6):493-9. doi: 10.1038/sj.mp.4000446.
A missense mutation in the human alpha synuclein gene was recently identified in some cases of familial Parkinson's disease (FPD). We have developed an antibody that recognizes the C-terminal 12 amino acids of the human alpha synuclein protein and have demonstrated that alpha synuclein is an abundant component of the Lewy bodies found within the degenerating neurons of patients with Parkinson's disease (PD). The presence of alpha synuclein in Lewy bodies of sporadic PD patients suggests a central role for alpha synuclein in the pathogenesis of PD.
最近在一些家族性帕金森病（FPD）病例中发现了人类α-突触核蛋白基因的错义突变。我们开发了一种能识别人类α-突触核蛋白C末端12个氨基酸的抗体，并证明α-突触核蛋白是帕金森病（PD）患者退化神经元中路易小体的丰富成分。散发性PD患者路易小体中α-突触核蛋白的存在表明α-突触核蛋白在PD发病机制中起核心作用。
