Han I H, Johnson A G
J Immunol. 1976 Aug;117(2):423-7.
Model systems for study of the action of adjuvants in immunodeficient states were developed in 10- to 14-day-old BALB/aj mice and aging BALB/aj mice (12 to 16 months). With sheep red blood cells as antigen polyadenylicpolyuridylic acid complexes (poly A:U) were found to be stimulatory in both the neonatal and aging mice. The effect of poly A:U was similar to that seen when 5 X 10(6) thymocytes from immunologically mature mice were given with antigen. Cell-free supernatant fluids induced by incubation of poly A:U with thymocytes likewise were capable of restoring the number of antibody-forming cells to normalcy in aging mice.
在10至14日龄的BALB/aj小鼠和老龄BALB/aj小鼠（12至16个月）中建立了用于研究免疫缺陷状态下佐剂作用的模型系统。以绵羊红细胞作为抗原，发现聚腺苷酸聚尿苷酸复合物（聚A:U）在新生小鼠和老龄小鼠中均具有刺激作用。聚A:U的作用与给免疫成熟小鼠的5×10⁶个胸腺细胞同时给予抗原时所观察到的作用相似。聚A:U与胸腺细胞孵育诱导产生的无细胞上清液同样能够使老龄小鼠中抗体形成细胞的数量恢复正常。
