Stroeher U H, Jedani K E, Manning P A
Microbial Pathogenesis Unit, Department of Microbiology and Immunology, University of Adelaide, Adelaide, S.A. 5005, Australia.
Gene. 1998 Nov 26;223(1-2):269-82. doi: 10.1016/s0378-1119(98)00407-7.
Vibrio cholerae and V. anguillarum are recognized as aquatic-borne human and fish pathogens, respectively. Based upon analyses of several genes and the presence of novel genetic elements it seems that these two species are very closely related. Studies in this laboratory have identified an association of IS1358 with rfb and capsule loci in these two species. The most recent findings suggest that IS1358 is associated with the rfb region in V. cholerae O1 and O139 and in V. anguillarum O1 and O2. In addition, the rfb region in both V. cholerae serogroups and in V. anguillarum O1 is limited at one end by gmhD. These features make it feasible to envisage a mechanism by which the evolution of new rfb genes is taking place involving IS1358 and the region around gmhD. Furthermore, it is possible to envisage that there is or has been an exchange of genetic material between these species leading to new rfb/capsule regions. This review examines the genetics and biosynthesis of the O-antigen and capsule of V. cholerae O1 and O139, as well as the V. anguillarum serogroup O1 and the role of IS1358. Throughout this review we have used the new nomenclature for rfb genes proposed by.
霍乱弧菌和鳗弧菌分别被认为是水生传播的人类和鱼类病原体。基于对多个基因的分析以及新遗传元件的存在，这两个物种似乎密切相关。本实验室的研究已确定IS1358与这两个物种的rfb和荚膜基因座有关联。最新研究结果表明，IS1358与霍乱弧菌O1和O139以及鳗弧菌O1和O2的rfb区域有关。此外，霍乱弧菌两个血清群以及鳗弧菌O1中的rfb区域在一端受gmhD限制。这些特征使得设想一种涉及IS1358和gmhD周围区域的新rfb基因进化机制成为可能。此外，可以设想这些物种之间存在或曾经存在遗传物质交换，从而导致新的rfb/荚膜区域。本综述研究了霍乱弧菌O1和O139以及鳗弧菌血清群O1的O抗原和荚膜的遗传学及生物合成，以及IS1358的作用。在本综述中，我们使用了所提出的rfb基因新命名法。
