Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
Churchill College, University of Cambridge, Storey's Way, Cambridge, CB3 0DS, UK.
Microb Genom. 2023 Apr;9(4). doi: 10.1099/mgen.0.000980.
Between 1965 and 1968, outbreaks of cholera in Sudan and former Czechoslovakia provoked considerable public health concern. These still represent important historical events that need to be linked to the growing genomic evidence describing the aetiological agent of cholera, . Whilst O1 serogroup are canonically associated with epidemic and pandemic cholera, these events were caused by a clone of toxigenic O37 that may be more globally distributed than just to Europe and North Africa. Understanding the biology of these non-O1 strains of is key to understanding how diseases like cholera continue to be globally important. In this article, we consolidate epidemiological, molecular and genomic descriptions of the bacteria responsible for these outbreaks. We attempt to resolve discrepancies in order to summarize the history and provenance of as many commonly used serogroup O37 strains as possible. Finally, we highlight the potential for whole-genome sequencing of O37 isolates from strain collections to shed light on the open questions that we identify.
1965 年至 1968 年间，苏丹和捷克斯洛伐克爆发的霍乱疫情引起了相当大的公众健康关注。这些仍然是重要的历史事件，需要将其与越来越多的基因组证据联系起来，这些证据描述了霍乱的病原体。虽然 O1 血清群通常与流行和大流行的霍乱有关，但这些事件是由产毒 O37 的一个克隆引起的，该克隆可能比欧洲和北非分布更广。了解这些非 O1 型霍乱弧菌的生物学特性是理解霍乱等疾病为何继续在全球范围内具有重要意义的关键。在本文中，我们综合了这些疫情中负责的细菌的流行病学、分子和基因组描述。我们试图解决差异，以尽可能总结出常用的 O37 血清群菌株的历史和来源。最后，我们强调了对菌株收集的 O37 分离株进行全基因组测序的潜力，以阐明我们发现的悬而未决的问题。
