Bachmeyer C, Leclerc-Landgraf N, Laurette F, Coutarel P, Cadranel J F, Médioni J, Dhôte R, Mougeot-Martin M
Department of Internal Medicine, Laennec Hospital, Creil, France.
Am J Gastroenterol. 1998 Dec;93(12):2565-7. doi: 10.1111/j.1572-0241.1998.00720.x.
We report the sudden onset of bilateral hearing loss in a patient with Crohn's disease while the intestinal disease was quiescent. Antibodies directed against collagen type II were detected in the serum. Dramatic improvement of his hearing was observed under corticosteroid therapy. Diagnosis of autoimmune sensorineural hearing loss was established. This condition could be considered as an extraintestinal manifestation of Crohn's disease. Early diagnosis is mandated, as prompt and intensive treatment with corticosteroids and/or immunosuppressive drugs is effective and could prevent irreversible hearing loss.
我们报告了1例克罗恩病患者在肠道疾病静止期突然出现双侧听力丧失。血清中检测到抗II型胶原抗体。在皮质类固醇治疗下，其听力显著改善。确诊为自身免疫性感音神经性听力损失。这种情况可被视为克罗恩病的肠外表现。由于使用皮质类固醇和/或免疫抑制药物进行迅速和强化治疗是有效的，且可预防不可逆性听力损失，因此必须进行早期诊断。
