de Visscher J G, Schaapveld M, Otter R, Visser O, van der Waal I
Department of Oral and Maxillofacial Surgery, Medisch Centrum Leeuwarden, Netherlands.
Oral Oncol. 1998 Sep;34(5):421-6. doi: 10.1016/s1368-8375(98)00029-3.
Descriptive epidemiological data of new cases of squamous cell carcinoma of the vermilion border of the lip in the Netherlands from 1989-94 inclusive are presented. Lip cancer represented 0.47 and 0.09% of all new malignancies in males and females, respectively. The lower lip was the most frequently affected site. The majority of the lip cancers were diagnosed in tumour stage I. The median age at diagnosis in males was 68 years, 5 years less than in females. The overall male-to-female ratio was 5.7. Age-adjusted incidence rates in males and females were 2.2 and 0.3 per 100,000 (ESR), respectively. The cumulative lifetime risk for developing lip cancer was 0.15 for males and 0.03 for females. Mortality/incidence ratios in males and females were 0.05 and 0.07, respectively. Differences in lip cancer incidence were observed between an urban and a rural area. There was a positive association between the occurrence of lip cancer and rural residence; rate ratios were 3.3 among males and 3.5 among females.
本文呈现了1989年至1994年（含）荷兰唇部唇红缘鳞状细胞癌新发病例的描述性流行病学数据。唇癌分别占男性和女性所有新发恶性肿瘤的0.47%和0.09%。下唇是最常受累部位。大多数唇癌在肿瘤I期被诊断出来。男性诊断时的中位年龄为68岁，比女性小5岁。总体男女比例为5.7。男性和女性的年龄调整发病率分别为每10万人2.2例和0.3例（欧洲标准人口）。男性患唇癌的累积终生风险为0.15，女性为0.03。男性和女性的死亡率/发病率分别为0.05和0.07。在城市和农村地区观察到唇癌发病率的差异。唇癌的发生与农村居住呈正相关；男性的率比为3.3，女性为3.5。
