Strik J J, Honig A, Lousberg R, Cheriex E C, Van Praag H M
Department of Psychiatry, Maastricht University Hospital, The Netherlands.
Int Clin Psychopharmacol. 1998 Nov;13(6):263-7. doi: 10.1097/00004850-199811000-00004.
Selective serotonin reuptake inhibitors (SSRIs) are the 'new' drugs of first choice for the treatment of depression in the older patient. Systematic studies on the effects of SSRIs on cardiac function are scarce, despite the high prevalence of cardiac disorders in the older depressed patient. This is a study which systematically assessed cardiac function by echocardiography in middle-aged and elderly depressed patients treated with SSRI. In a double-blind randomized trial, 20 patients were assigned to receive fluvoxamine 100 mg/day [DOSAGE ERROR CORRECTED] or fluoxetine 20 mg/day [DOSAGE ERROR CORRECTED] for 6 weeks. Cardiac function was assessed by left ventricle ejection fraction, aortic flow integral and early or passive/late or active mitral inflow, and electrocardiography. Neither SSRI significantly affected cardiac function. Compared with patients without a history of myocardial infarction and/or hypertension, patients with such a history showed a significant improvement in left ventricular ejection fraction. Despite our small study sample, these data indicate that both fluoxetine and fluvoxamine do not affect cardiac function adversely.
选择性5-羟色胺再摄取抑制剂（SSRIs）是治疗老年患者抑郁症的“新型”首选药物。尽管老年抑郁症患者心脏疾病的患病率很高，但关于SSRIs对心脏功能影响的系统性研究却很匮乏。这是一项通过超声心动图对接受SSRI治疗的中老年抑郁症患者的心脏功能进行系统性评估的研究。在一项双盲随机试验中，20名患者被分配接受每天100毫克氟伏沙明[剂量已校正]或每天20毫克氟西汀[剂量已校正]，为期6周。通过左心室射血分数、主动脉血流积分以及二尖瓣流入的早期或被动/晚期或主动情况，还有心电图来评估心脏功能。两种SSRI均未对心脏功能产生显著影响。与没有心肌梗死和/或高血压病史的患者相比，有此类病史的患者左心室射血分数有显著改善。尽管我们的研究样本较小，但这些数据表明氟西汀和氟伏沙明均不会对心脏功能产生不利影响。
