Luc J, Mroz C, Roques C, Ducani-Federlin M
Laboratoire de Bactériologie, Virologie et Microbiologie Industrielle, Faculté des Sciences Pharmaceutiques, Toulouse, France.
Bull Group Int Rech Sci Stomatol Odontol. 1998 Apr-Sep;40(2-3):102-8.
Antiseptic activity of five mouthrinses containing 0.10%, 0.12% and 0.20% chlorhexidine, as well as aqueous chlorhexidine solutions at the same concentrations were determined under usual conditions (advocated dilutions by the manufacturers and short contact time) and according to French Pharmacopoeia recommendations. The three aqueous solutions and two mouthrinses containing 0.12% chlorhexidine were not antiseptic according to the fixed criteria. Bactericidal activities of the different dilutions of products were tested with an appropriate micromethod against nine-bacterial species involved in periodontal disease. Efficacity of mouthrinses were variable and were not agreed with the aqueous chlorhexidine-corresponding solutions: the mouthrinse containing 0.10% chlorhexidine reached 0.20% aqueous solution efficacy, and the mouthrinses containing 0.12% chlorhexidine were generally less active than the 0.12% aqueous chlorhexidine solution. Therefore, antibacterial activity of this type of product cannot be anticipated with the sole concentration factor, excipients playing essential part in the chlorhexidine activity.
按照法国药典的建议，在通常条件下（生产商推荐的稀释度和短接触时间），测定了含0.10%、0.12%和0.20%氯己定的五种漱口水以及相同浓度的氯己定水溶液的抗菌活性。根据既定标准，三种水溶液和两种含0.12%氯己定的漱口水没有抗菌作用。使用适当的微量方法测试了不同稀释度产品对九种参与牙周疾病的细菌的杀菌活性。漱口水的功效各不相同，且与相应的氯己定水溶液不一致：含0.10%氯己定的漱口水达到了0.20%水溶液的功效，而含0.12%氯己定的漱口水通常比0.12%氯己定水溶液的活性低。因此，不能仅通过浓度因素来预测这类产品的抗菌活性，辅料在氯己定的活性中起着至关重要的作用。
