Lin L N, Wang W T, Xu Z J
Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical College, Zhejiang.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 May;17(5):261-3.
To explore the protective effect of Ligustrazine in treating myocardial ischemia, and reperfusion injury.
The activities of serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and lactic dehydrogenase (LDH) and the amount of malondialdehyde (MDA) as well as the effects of Ligustrazine (LGT) on them were determined in 16 patients with cardiopulmonary bypass, who were, scheduled for elective cardiac surgery, were randomly divided into control group and LGT group. Ligustrazine was given by intravenous drip within 2-3 minute with a definite speed before occlusion and immediately after release respectively. Their venous blood samples were collected to measure the serum levels of SOD, GSH-Px, LDH and MDA by biochemical methods before the occlusion of aorta, at 30 minutes of occlusion and at 30 minutes after release respectively.
There were significantly and very significantly differences between the values of control group and LGT group.
LGT could effectively protect the myocardium from ischemia and reperfusion injury.
探讨川芎嗪对心肌缺血及再灌注损伤的保护作用。
选取16例行择期心脏手术的体外循环患者，随机分为对照组和川芎嗪组，测定血清超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、乳酸脱氢酶（LDH）活性及丙二醛（MDA）含量，以及川芎嗪对其的影响。在阻断前及松开后分别于2 - 3分钟内以一定速度静脉滴注川芎嗪。分别于主动脉阻断前、阻断30分钟及松开后30分钟采集静脉血样本，采用生化方法测定血清SOD、GSH-Px、LDH及MDA水平。
对照组和川芎嗪组的值存在显著及极显著差异。
川芎嗪可有效保护心肌免受缺血及再灌注损伤。
