Jones J B, Schoenleber D B, Gillen J P
Emergency Medicine and Trauma Center, Indiana University School of Medicine, Indianapolis 46206-1367, USA.
Acad Emerg Med. 1998 Dec;5(12):1150-6. doi: 10.1111/j.1553-2712.1998.tb02687.x.
To evaluate two solutions, lactated Ringer's (LR) and a balanced salt solution (BSS Plus, Alcon Laboratories, Ft. Worth, TX), compared with normal saline solution (NSS), for ocular irrigation in healthy adult volunteers with and without the Morgan therapeutic lens (MTL).
This was a prospective, double-blind, randomized study of healthy volunteers who were at least 18 years of age. Exclusion criteria included the use of analgesics within four hours of the study. A complete ophthalmologic examination was performed at baseline and at the completion of the study. Following randomization and prior to any intervention, baseline discomfort scores were obtained by means of a verbally administered, horizontal, 100-mm, unnumbered analog discomfort scale. Both eyes of each volunteer were irrigated simultaneously for 15 minutes, with additional discomfort scores being recorded every 5 minutes using the same 100-mm, unnumbered analog discomfort scale. A global evaluation to assess the method of irrigation and the solutions used for irrigation was completed by both the physician blinded to the treatment groups and the volunteers. The volunteers were continuously monitored for any adverse effects resulting from the irrigation solutions or MTL.
Sixty-three volunteers were recruited into the study, with 61 entered in the final analysis. Age and gender were balanced within each group. There was no significant difference in discomfort scores between the two groups; however, all discomfort scores decreased over time (p = 0.008). A lens-solution interaction was identified, with LR being the most tolerated when administered with the MTL. A statistically higher ocular pH difference was seen between the pre- and postirrigation readings for the control eye in volunteers irrigated with MTL (p = 0.046). Analysis of the global evaluations for each group revealed no difference in the distributions of physician and volunteer scores. No adverse event was reported in either group.
There does not appear to be any difference in discomfort scores between the ocular irrigation fluids when used without the MTL. Overall, the use of the MTL appears well tolerated by healthy, adult volunteers. However, there does appear to be a significant lens-solution effect on volunteers' discomfort scores, with LR having significantly lower discomfort scores when used for ocular irrigation with the MTL. The authors conclude that the use of the MTL for ocular irrigation is well tolerated and recommend using LR as the irrigation solution for maximal patient comfort.
评估两种溶液，即乳酸林格氏液（LR）和一种平衡盐溶液（BSS Plus，爱尔康实验室，得克萨斯州沃思堡），与生理盐水溶液（NSS）相比，在有和没有摩根治疗镜片（MTL）的健康成年志愿者眼中进行冲洗的效果。
这是一项针对至少18岁健康志愿者的前瞻性、双盲、随机研究。排除标准包括在研究前四小时内使用镇痛药。在基线和研究结束时进行全面的眼科检查。随机分组后且在任何干预之前，通过口头给予的、水平的、100毫米、无编号的类似物不适量表获得基线不适评分。每位志愿者的双眼同时冲洗15分钟，每隔5分钟使用相同的100毫米、无编号的类似物不适量表记录额外的不适评分。由对治疗组不知情的医生和志愿者完成一项全面评估，以评估冲洗方法和用于冲洗的溶液。持续监测志愿者是否出现由冲洗液或MTL引起的任何不良反应。
63名志愿者被招募进入研究，61名进入最终分析。每组内年龄和性别均衡。两组之间的不适评分无显著差异；然而，所有不适评分随时间下降（p = 0.008）。发现镜片 - 溶液相互作用，当与MTL一起使用时，LR的耐受性最佳。在用MTL冲洗的志愿者中，对照眼冲洗前后的眼部pH差异在统计学上更高（p = 0.046）。对每组的全面评估分析显示，医生和志愿者评分的分布没有差异。两组均未报告不良事件。
在不使用MTL时，眼部冲洗液之间的不适评分似乎没有差异。总体而言，健康成年志愿者对MTL的使用耐受性良好。然而，MTL对志愿者的不适评分似乎确实有显著的镜片 - 溶液效应，当与MTL一起用于眼部冲洗时，LR的不适评分显著更低。作者得出结论，MTL用于眼部冲洗耐受性良好，并建议使用LR作为冲洗液以最大程度提高患者舒适度。
