Herr R D, White G L, Bernhisel K, Mamalis N, Swanson E
Department of Surgery, University of Utah Medical School, Salt Lake City.
Am J Emerg Med. 1991 May;9(3):228-31. doi: 10.1016/0735-6757(91)90082-u.
This study tested the hypothesis that four ocular irrigating solutions were equally irritating during copious irrigation. We conducted a prospective, double-blind study of patients with chemical exposure to the eye. Each underwent cross-over irrigation with all of the following in random order: normal saline (NS), lactated Ringer's (LR), normal saline adjusted to pH 7.4 with sodium bicarbonate (NS + Bicarb), and Balanced Saline Solution Plus (BSS Plus, Alcon Laboratories, Fort Worth, TX). Compared with traditional NS and LR, NS + Bicarb tended to be more comfortable. BSS Plus was statistically superior (P less than .05) to NS and preferred over LR and NS + Bicarb. Three patients demanded discontinuance of NS or NS + Bicarb infusions. All solutions had comparable normalization of conjunctival pH and degree of injection. Alternate solutions including BSS Plus should be considered for use in those patients whose poor tolerance to normal saline threatens to delay or interrupt eye irrigation following a chemical injury.
在大量冲洗过程中，四种眼部冲洗液的刺激性相同。我们对眼部遭受化学物质暴露的患者进行了一项前瞻性双盲研究。每位患者均按随机顺序接受以下所有冲洗液的交叉冲洗：生理盐水（NS）、乳酸林格氏液（LR）、用碳酸氢钠将pH值调至7.4的生理盐水（NS + 碳酸氢盐）以及平衡盐溶液加（BSS Plus，爱尔康实验室，得克萨斯州沃思堡）。与传统的NS和LR相比，NS + 碳酸氢盐往往更舒适。BSS Plus在统计学上优于NS（P小于0.05），且比LR和NS + 碳酸氢盐更受青睐。三名患者要求停止NS或NS + 碳酸氢盐冲洗。所有冲洗液在结膜pH值正常化和充血程度方面具有可比性。对于那些对生理盐水耐受性差可能会延迟或中断化学伤后眼部冲洗的患者，应考虑使用包括BSS Plus在内的替代冲洗液。
