Du Cailar J, Huguenard P, Kielen J, Griffe D
Ann Anesthesiol Fr. 1975;16 Spec No 2-3:196-206.
Proposed since 1938 as a treatment for pulmonary edema, continuous positive pressure ventilation (PPP) still called teleexpiratory positive pressure in France (PPTE) and "Positive End Expiratory Pressure" (PEEP) or even "Continuous Pressure Breathing" (CPPB) in Anglo-Saxon countries, has taken a place in the first line of therapy in refractory hypoxia and particulary when the latter originate from lesional pulmonary edema. The aim of PPP is to open up the alveolar territories by calling on their elastic properties, to fight against micro-atelectasis and bronchial collapse, to diminish the closing volume, to increase the FRC, thereby improve VA/Qc, decrease Qs/Qt and increase PaO2. Furthermore, in the particular case of pulmonary edema, PPP acts against the hydrostatic pressure by increasing the external component of the transmural pressure and by evening out pulmonary capillary blood flow.
自1938年起被提议作为治疗肺水肿的方法，持续气道正压通气（PPP）在法国仍被称为呼气末正压（PPTE），在盎格鲁-撒克逊国家被称为“呼气末正压”（PEEP）甚至“持续压力呼吸”（CPPB），在难治性低氧血症的一线治疗中占据了一席之地，尤其是当后者源于损伤性肺水肿时。PPP的目的是通过利用肺泡的弹性特性来开放肺泡区域，对抗微小肺不张和支气管塌陷，减少闭合气量，增加功能残气量，从而改善通气/血流比值（VA/Qc），降低肺内分流（Qs/Qt）并提高动脉血氧分压（PaO2）。此外，在肺水肿的特殊情况下，PPP通过增加跨壁压的外部成分并使肺毛细血管血流均匀分布来对抗静水压。
