注射10000国际单位人绒毛膜促性腺激素（hCG）后，血浆中hCG水平较低并不会减少接受辅助生殖患者回收的卵母细胞数量或其成熟度。
Low plasma levels of hCG after 10,000-IU hCG injection do not reduce the number or maturation of oocytes recovered in patients undergoing assisted reproduction.
作者信息
al-Hassan S, Fishel S, Fleming S, Thornton S
机构信息
Nottingham University Research and Treatment Unit in Reproduction (NURTURE), Department of Obstetrics & Gynaecology, UK.
出版信息
J Assist Reprod Genet. 1998 Nov;15(10):583-6. doi: 10.1023/a:1020325125881.
PURPOSE
Our purpose was to determine whether there is a correlation between human chorionic gonadotropin (hCG) blood levels and oocyte maturation.
METHODS
Three samples of blood were obtained at different times from hCG administration as follows: 12 hr, 36 hr, during oocyte recovery, and at 84 hr, when the patient comes for embryo transfer.
RESULTS
A total of 5036 oocytes was retrieved from 404 patients prospectively recruited between April 1996 and March 1997. The percentage of metaphase-II oocytes at different blood levels ranged from 84 to 88%. The general trend does not show any significant increase in percentage of metaphase-II oocytes in association with an increasing serum hCG concentration.
CONCLUSIONS
The results of this study suggest that at 12, 36, and 84 hr after hCG administration, levels as low as 50, 45, and 9 IU/L of hCG, respectively, are equally potent as higher levels at initiating maximal oocyte maturity.
目的
我们的目的是确定人绒毛膜促性腺激素（hCG）血药浓度与卵母细胞成熟之间是否存在相关性。
方法
在注射hCG后的不同时间采集三份血样，具体如下：注射后12小时、36小时、卵母细胞回收时以及患者进行胚胎移植的84小时。
结果
前瞻性招募了1996年4月至1997年3月期间的404例患者，共获取5036枚卵母细胞。不同血药浓度下处于中期II的卵母细胞百分比在84%至88%之间。总体趋势并未显示随着血清hCG浓度升高，处于中期II的卵母细胞百分比有任何显著增加。
结论
本研究结果表明，在注射hCG后12、36和84小时，hCG水平分别低至50、45和9 IU/L时，在启动最大卵母细胞成熟方面与较高水平同样有效。
Zotero 插件