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RNA病毒的准种结构与持续性

Quasispecies structure and persistence of RNA viruses.

作者信息

Domingo E, Baranowski E, Ruiz-Jarabo C M, Martín-Hernández A M, Sáiz J C, Escarmís C

机构信息

Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Cantoblanco, Spain.

出版信息

Emerg Infect Dis. 1998 Oct-Dec;4(4):521-7. doi: 10.3201/eid0404.980402.

Abstract

Viral quasispecies are closely related (but nonidentical) mutant and recombinant viral genomes subjected to continuous genetic variation, competition, and selection. Quasispecies structure and dynamics of replicating RNA enable virus populations to persist in their hosts and cause disease. We review mechanisms of viral persistence in cells, organisms, and populations of organisms and suggest that the critical interplay between host and viral influences (including in some cases the quasispecies organization) is the main driving force for long-term survival of viruses in nature.

摘要

病毒准种是密切相关(但不相同)的突变和重组病毒基因组,它们经历着持续的遗传变异、竞争和选择。复制性RNA的准种结构和动态使得病毒群体能够在其宿主中持续存在并引发疾病。我们综述了病毒在细胞、生物体及生物群体中持续存在的机制,并提出宿主与病毒影响(包括在某些情况下的准种组织)之间的关键相互作用是病毒在自然界长期生存的主要驱动力。

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