Boyd H L, Rosen S D, Rimoldi O, Cunningham V J, Camici P G
MRC Cyclotron Unit, Hammersmith Hospital, London, United Kingdom.
G Ital Cardiol. 1998 Nov;28(11):1207-14.
Accurate assessment of left ventricular (LV) volumes provides important insights into myocardial function, being particularly important for diseases of the heart in which there is progressive dilatation of the LV, such as remodeling after myocardial infarction. We have recently validated a method for measuring LV volumes using gated positron emission tomography (PET) with oxygen-15 labeled carbon monoxide (C15O). The present study was performed to establish normal values for LV volumes, in absolute units, using this technique.
Forty subjects [21 males and 19 females; age 49 +/- 13 years (mean +/- SD), range 24-80; body surface area (BSA) range 1.50-2.18 m2] were studied. End diastolic (EDV) and end systolic volumes (ESV) were calculated by determining the edge of the end diastolic and end systolic blood pool images (obtained using PET with C15O) and summing the volume of the voxels comprising the blood pool.
For the overall study population, EDV was 109 +/- 20 ml and ESV 37 +/- 12 ml. When stratified according to gender, these values were: in males, EDV was 117 +/- 18 ml and ESV 42 +/- 18 ml; in females, EDV was 100 +/- 19 ml and ESV 32 +/- 8 ml. The differences between gender groups (EDV: p = 0.0027, ESV: p = 0.0029) were eliminated when volumes were corrected for BSA.
These data will form a database of normal values for comparison with pathological conditions of the heart. PET quantification of LV volumes offers a means of measurement of function using an imaging modality that can also assess regional myocardial perfusion and metabolism during the same study session.
准确评估左心室（LV）容积对于了解心肌功能具有重要意义，这对于左心室进行性扩张的心脏疾病，如心肌梗死后重塑，尤为重要。我们最近验证了一种使用门控正电子发射断层扫描（PET）结合氧 - 15标记一氧化碳（C15O）测量左心室容积的方法。本研究旨在使用该技术建立以绝对单位表示的左心室容积正常值。
对40名受试者进行了研究[21名男性和19名女性；年龄49±13岁（平均值±标准差），范围24 - 80岁；体表面积（BSA）范围1.50 - 2.18 m²]。通过确定舒张末期和收缩末期血池图像的边缘（使用PET结合C15O获得）并对构成血池的体素体积求和来计算舒张末期容积（EDV）和收缩末期容积（ESV）。
对于整个研究人群，EDV为109±20 ml，ESV为37±12 ml。按性别分层时，这些值分别为：男性，EDV为117±18 ml，ESV为42±18 ml；女性，EDV为100±19 ml，ESV为32±8 ml。当对容积进行体表面积校正后，性别组之间的差异（EDV：p = 0.0027，ESV：p = 0.0029）消除。
这些数据将形成一个正常值数据库，用于与心脏病理状况进行比较。PET对左心室容积的定量提供了一种测量功能的方法，该成像方式还可以在同一研究过程中评估局部心肌灌注和代谢。
