Wei E, Loh H
Science. 1976 Sep 24;193(4259):1262-3. doi: 10.1126/science.986687.
Methionine-enkephalin and beta-endorphin, endogenous peptides with activities similar to those of opiates, were infused for 70 hours into the periaqueductal gray-fourth ventricular space of the rat brain. When challenged with a naloxone, a specific opiate antagonist, these animals manifested a typical morphine-like withdrawal syndrome. These results show that such peptides can cause physical dependence.
甲硫氨酸脑啡肽和β-内啡肽，这两种具有与阿片类物质相似活性的内源性肽，被注入大鼠脑导水管周围灰质-第四脑室区域达70小时。当用特异性阿片类拮抗剂纳洛酮进行激发时，这些动物表现出典型的类吗啡戒断综合征。这些结果表明，此类肽可导致身体依赖性。
