Lonovics J, Madácsy L, Szepes A, Szilvássy Z, Velösy B, Varró V
First Dept. of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Scand J Gastroenterol Suppl. 1998;228:73-89. doi: 10.1080/003655298750026606.
This review is intended to summarize current information on neurohumoral regulation of the gallbladder and sphincter of Oddi motility under both physiological and pathological circumstances with emphasis on Hungarian contributions to today's knowledge. The mechanism of action of neurohumoral agents that interact on these segments of the biliary tract, and the explored details of the stimulation-contraction/relaxation coupling process of these substances, will be discussed. A modified classification of biliary tract motility disorders with new diagnostic and therapeutic approaches will also be provided. This information will aid understanding of the pathogenesis of motor disorders of the gallbladder and sphincter of Oddi, and will indicate possibilities for pharmacological exploitation in the treatment of diseases resulting from biliary tract motility abnormalities.
本综述旨在总结生理和病理情况下胆囊及Oddi括约肌运动的神经体液调节的当前信息，重点介绍匈牙利人对当今知识的贡献。将讨论与胆道这些节段相互作用的神经体液因子的作用机制，以及这些物质刺激-收缩/舒张偶联过程的详细研究情况。还将提供一种改良的胆道运动障碍分类方法以及新的诊断和治疗方法。这些信息将有助于理解胆囊和Oddi括约肌运动障碍的发病机制，并指出在治疗由胆道运动异常引起的疾病时进行药理学开发的可能性。
