Cheng H, Wang W, Liu S
Department of Neural Surgery, 3rd People's Hospital of Chengdu, Sichuan, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 1997 May;11(3):129-31.
In order to investigate the possibility of porous hydroxyapatite ceramics (HAC) in the repair of skull bone defect, twenty-four rabbits were used. The bone defect model was created by operation to obtain a defect in parietal bone in a size of 1 cm x 1 cm. Filled the defect with HAC and methyl-methacrylate-syrene copolymer (MMAS) to fill the defect as control. At 1st, 2nd and 3rd months after operation, behavior of the rabbits was observed and then these animals were sacrificed and specimens were examined under microscope. Results showed as follows: after operation, behavior of all animals were normal. By histological examination, it was found that in HAC group, there were granulation tissue, fibrous tissue and newly formed vessels grew into the pores and the osteoblasts formed osseous trabeculae. There was no inflammatory cell infiltration. In the MMAS grafted asea, there was formation of fibrous membrane. It suggested that HAC might be a good material for bone substitute in repair of skull bone defect.
为了研究多孔羟基磷灰石陶瓷（HAC）修复颅骨缺损的可能性，使用了24只兔子。通过手术创建骨缺损模型，以获得大小为1厘米×1厘米的顶骨缺损。用HAC填充缺损，并以甲基丙烯酸甲酯 - 苯乙烯共聚物（MMAS）填充缺损作为对照。在术后第1、2和3个月，观察兔子的行为，然后处死这些动物并在显微镜下检查标本。结果如下：术后所有动物行为正常。通过组织学检查发现，在HAC组中，有肉芽组织、纤维组织和新形成的血管长入孔隙，成骨细胞形成骨小梁。无炎性细胞浸润。在MMAS移植区域，有纤维膜形成。这表明HAC可能是修复颅骨缺损的良好骨替代材料。
