Kim H, Moon K H, Ryu S Y, Moon D C, Lee C K
College of Pharmacy, Kyungsung University, Pusan, Korea.
Arch Pharm Res. 1998 Dec;21(6):734-7. doi: 10.1007/BF02976767.
The hexane fractions from methanolic extracts of Anetheum graveolens L. (Umbelliferae) and Acorus gramineus Soland. (Araceae), revealed potent inhibitory activities against the resistance of multi-drug resistant Staphylococcus aureus SA2 when combined with ampicillin (Am) or chloramphenicol (Cm). As active principles, carvone and the liquid mixture containing carvone from Anetheum graveolens L. and a liquid mixture mainly consisting of benzoic acid phenylmethyl ester (benzyl benzoate) from Acorus gramineus Soland, were identified. They showed resistance inhibition at the level of 20-50 micrograms/ml when combined with 100 or 50 micrograms/ml of Am or Cm, respectively.
来自伞形科植物莳萝（Anethum graveolens L.）和天南星科植物石菖蒲（Acorus gramineus Soland.）甲醇提取物的己烷馏分，与氨苄青霉素（Am）或氯霉素（Cm）联合使用时，对多重耐药金黄色葡萄球菌SA2的耐药性显示出强大的抑制活性。已鉴定出香芹酮以及莳萝中含香芹酮的液体混合物和石菖蒲中主要由苯甲酸苄酯组成的液体混合物作为活性成分。当它们分别与100或50微克/毫升的Am或Cm联合使用时，在20 - 50微克/毫升的水平上显示出耐药性抑制作用。
