人参总皂苷对牛肾上腺酪氨酸羟化酶的作用。

Effect of ginseng total saponin on bovine adrenal tyrosine hydroxylase.

作者信息

Kim H S, Zhang Y H, Fang L H, Lee M K

机构信息

College of Pharmacy, Chungbuk National University, Cheongju, Korea.

出版信息

Arch Pharm Res. 1998 Dec;21(6):782-4. doi: 10.1007/BF02976777.

DOI:10.1007/BF02976777

PMID:9868557

Abstract

Ginseng total saponin (GTS) can modulate dopaminergic activity at both presynaptic and postsynaptic dopamine receptors (Kim et al., 1998). The present study investigated the effect of GTS on the bovine adrenal tyrosine hydroxylase (TH), which catalyze L/tyrosine to DOP. GTS inhibited the bovine adrenal TH by 42.4, 51.5 and 55.3% at concentrations of 40, 80 and 100 micrograms/ml, respectively. The IC50 value of GTS was 77.5 micrograms/ml. GTS exhibited noncompetitive inhibition with a substrate L-tyrosine. The Ki value was 155 micrograms/ml.

摘要

人参总皂苷（GTS）可调节突触前和突触后多巴胺受体处的多巴胺能活性（Kim等人，1998年）。本研究调查了GTS对牛肾上腺酪氨酸羟化酶（TH）的影响，该酶催化L/酪氨酸生成多巴。GTS在浓度分别为40、80和100微克/毫升时，对牛肾上腺TH的抑制率分别为42.4%、51.5%和55.3%。GTS的IC50值为77.5微克/毫升。GTS对底物L-酪氨酸表现出非竞争性抑制。Ki值为155微克/毫升。