Revathi G, Shannon K P, Stapleton P D, Jain B K, French G L
Department of Microbiology, University College of Medical Sciences, Delhi, India.
J Hosp Infect. 1998 Dec;40(4):295-302. doi: 10.1016/s0195-6701(98)90307-3.
A strain of Salmonella senftenberg resistant to ceftazidime, gentamicin, chloramphenicol and ciprofloxacin was isolated from burn wounds of eight patients on a burns ward of a hospital in Delhi, India. The organism, which had probably been spread from patient to patient on staff hands, produced the extended-spectrum beta-lactamase SHV-5 and the aminoglycoside-modifying enzymes AAC(3)II + AAC(6'). The strain was not isolated from stool cultures of any of the patients or staff, apart from the index patient who had a history of diarrhoea and fever before admission. The outbreak ended in three weeks, after the implementation of strict handwashing. This is the first report of SHV-5 beta-lactamase in Salmonella spp. and also the first report of SHV-5 in India. The extended-spectrum beta-lactamases that have been reported in Salmonella spp. now include the Group 2 be enzymes SHV-2, SHV-5, TEM-3, TEM-25, TEM-27, CTX-M2, PER-1 and PER-2, and the Group 1 enzymes DHA-1 and CMY-2. The types of extended-spectrum beta-lactamases produced by salmonellas, their association with aminoglycoside resistance and their geographical distribution are now similar to those seen in klebsiella. Increasing antibiotic resistance in these organisms is reducing therapeutic options for the treatment of invasive disease.
从印度德里一家医院烧伤病房8名患者的烧伤创面分离出一株对头孢他啶、庆大霉素、氯霉素和环丙沙星耐药的肠炎沙门氏菌。该菌株可能通过医护人员的手在患者之间传播，产生了超广谱β-内酰胺酶SHV-5和氨基糖苷类修饰酶AAC(3)II + AAC(6')。除了入院前有腹泻和发热病史的首例患者外，在任何患者或医护人员的粪便培养物中均未分离到该菌株。在实施严格的洗手措施后，疫情在三周内结束。这是沙门氏菌属中SHV-5β-内酰胺酶的首次报道，也是印度首次报道SHV-5。沙门氏菌属中已报道的超广谱β-内酰胺酶现在包括2组be酶SHV-2、SHV-5、TEM-3、TEM-25、TEM-27、CTX-M2、PER-1和PER-2，以及1组酶DHA-1和CMY-2。沙门氏菌产生的超广谱β-内酰胺酶类型、它们与氨基糖苷类耐药性的关联及其地理分布现在与克雷伯菌属中所见的相似。这些微生物中抗生素耐药性的增加正在减少侵袭性疾病治疗的选择。
