用于分析同卵双胞胎家庭数据的遗传模型。
Genetic models for the analysis of data from the families of identical twins.
作者信息
Nance W E, Corey L A
出版信息
Genetics. 1976 Aug;83(4):811-26. doi: 10.1093/genetics/83.4.811.
Abstract
Genetic models are described which exploit the unique relationships that exist within the families of identical twins to obtain weighted least squares estimates of additive, dominance and epistatic components of genetic variance as well as estimates of the contributions of X-linked genes, maternal effects and three sources of environmental variation. Since all of the relationships required to achieve a resolution of these variance components are contained within each family unit, the model would appear to be superior to previous approaches to the analysis of quantitative traits in man.
摘要
文中描述了一些遗传模型，这些模型利用同卵双胞胎家族中存在的独特关系，来获得遗传方差的加性、显性和上位性成分的加权最小二乘估计，以及X连锁基因的贡献、母体效应和三种环境变异来源的估计。由于实现这些方差成分分解所需的所有关系都包含在每个家族单元中，该模型似乎优于以往对人类数量性状进行分析的方法。
相似文献
1
Genetic models for the analysis of data from the families of identical twins.用于分析同卵双胞胎家庭数据的遗传模型。
Genetics. 1976 Aug;83(4):811-26. doi: 10.1093/genetics/83.4.811.
2
Genetic studies of the offspring of identical twins: a model for the analysis of quantitative inheritance in man.同卵双胞胎后代的遗传学研究：人类数量遗传分析的一个模型
Acta Genet Med Gemellol (Roma). 1976;25:103-13. doi: 10.1017/s0001566000013933.
3
Dominance and environmental variances: their effect on heritabilities estimated from twin data.显性和环境方差：它们对根据双胞胎数据估计的遗传力的影响。
Hum Hered. 1977;27(1):9-21. doi: 10.1159/000152848.
4
The monozygotic twin half-sib method for analysing maternal effects and sex-linkage in humans.
Heredity (Edinb). 1981 Apr;46(Pt 2):227-38. doi: 10.1038/hdy.1981.30.
5
The advantages of analysing human variation using twins and twin half-sibs and cousins.
Heredity (Edinb). 1981 Oct;47(2):221-36. doi: 10.1038/hdy.1981.78.
6
Twin-family studies of perceptual speed ability. II. Parameter estimation.
Behav Genet. 1981 Nov;11(6):565-75. doi: 10.1007/BF01065791.
7
Detecting sex-associated variation with the families of MZ and DZ twins.利用同卵双胞胎和异卵双胞胎家族检测性别相关变异。
Acta Genet Med Gemellol (Roma). 1984;33(2):287-301. doi: 10.1017/s0001566000007339.
8
Aggregation of blood pressure in the families of identical twins.
Am J Epidemiol. 1979 May;109(5):503-11. doi: 10.1093/oxfordjournals.aje.a112707.
9
Variance of occlusion traits in twins.双胞胎咬合特征的方差
J Craniofac Genet Dev Biol. 1981;1(2):217-27.
10
The problem of genotype-environment correlation in the estimation of heritability from monozygotic and dizygotic twins.在通过同卵双胞胎和异卵双胞胎估计遗传力时的基因型-环境相关性问题。
Acta Genet Med Gemellol (Roma). 1976;25:86-99. doi: 10.1017/s000156600001391x.
引用本文的文献
1
Children of the Twins Early Development Study (CoTEDS): A Children-of-Twins Study.双胞胎儿童早期发展研究（CoTEDS）：一项双胞胎后代研究。
Twin Res Hum Genet. 2019 Dec;22(6):514-522. doi: 10.1017/thg.2019.61. Epub 2019 Sep 9.
2
Partitioning Phenotypic Variance Due to Parent-of-Origin Effects Using Genomic Relatedness Matrices.使用基因组亲缘关系矩阵划分源于亲本效应的表型变异
Behav Genet. 2018 Jan;48(1):67-79. doi: 10.1007/s10519-017-9880-0. Epub 2017 Nov 2.
3
Parental Separation and Offspring Alcohol Involvement: Findings from Offspring of Alcoholic and Drug Dependent Twin Fathers.父母离异与子女饮酒问题：来自酗酒和吸毒成瘾双胞胎父亲的子女的研究结果
Alcohol Clin Exp Res. 2015 Jul;39(7):1166-73. doi: 10.1111/acer.12766. Epub 2015 Jun 8.
4
A narrow heritability evaluation of gestational age at birth.出生孕周的狭义遗传力评估。
Hum Genet. 2015 Jul;134(7):809-11. doi: 10.1007/s00439-015-1574-1. Epub 2015 Jun 3.
5
Parental separation and early substance involvement: results from children of alcoholic and cannabis dependent twins.父母离异与早期物质滥用：酒精和大麻依赖双生子子女的研究结果。
Drug Alcohol Depend. 2014 Jan 1;134:78-84. doi: 10.1016/j.drugalcdep.2013.09.010. Epub 2013 Sep 19.
6
Critical need for family-based, quasi-experimental designs in integrating genetic and social science research.迫切需要基于家庭的准实验设计来整合遗传和社会科学研究。
Am J Public Health. 2013 Oct;103 Suppl 1(Suppl 1):S46-55. doi: 10.2105/AJPH.2013.301252. Epub 2013 Aug 8.
7
Unraveling the effect of genes and environment in the transmission of parental antisocial behavior to children's conduct disturbance, depression and hyperactivity.揭示基因和环境在父母反社会行为向儿童行为障碍、抑郁和多动传递中的作用。
J Child Psychol Psychiatry. 2012 Jun;53(6):668-77. doi: 10.1111/j.1469-7610.2011.02494.x. Epub 2011 Dec 6.
8
A Genetically Informed Study of the Intergenerational Transmission of Marital Instability.一项关于婚姻不稳定代际传递的基因学研究。
J Marriage Fam. 2007 Aug 1;69(3):793-809. doi: 10.1111/j.1741-3737.2007.00406.x.
9
The mediating effect of parental neglect on adolescent and young adult anti-sociality: a longitudinal study of twins and their parents.父母忽视对青少年和青年反社会行为的中介作用：双胞胎及其父母的纵向研究。
Behav Genet. 2010 Jul;40(4):425-37. doi: 10.1007/s10519-010-9336-2. Epub 2010 Feb 25.
10
Are extended twin family designs worth the trouble? A comparison of the bias, precision, and accuracy of parameters estimated in four twin family models.扩展的双胞胎家庭设计是否值得麻烦？四种双胞胎家庭模型中参数估计的偏差、精度和准确性比较。
Behav Genet. 2010 May;40(3):377-93. doi: 10.1007/s10519-009-9320-x. Epub 2009 Dec 16.
本文引用的文献
1
Theory of quantitative genetics: synthesis.
Cold Spring Harb Symp Quant Biol. 1955;20:93-102. doi: 10.1101/sqb.1955.020.01.011.
2
Comparison of the biometrical genetical, MAVA, and classical approaches to the analysis of human behavior.生物统计学遗传学、多变量分析方差（MAVA）以及经典方法在人类行为分析中的比较。
Psychol Bull. 1970 May;73(5):311-49. doi: 10.1037/h0029135.
3
Analysis of family resemblance. II. A linear model for familial correlation.家族相似性分析。II. 家族相关性的线性模型。
Am J Hum Genet. 1974 May;26(3):331-59.
4
Choice of an estimate of genetic variance from twin data.从双胞胎数据中选择遗传方差估计值的方法。
Am J Hum Genet. 1974 Mar;26(2):154-61.
5
6
Sampling variances in twin and sibling studies of man.
Hum Hered. 1974;24(4):363-72. doi: 10.1159/000152672.
Zotero 插件