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一名肾移植受者发生空肠弯曲菌血症和吉兰-巴雷综合征

Campylobacter jejuni bacteremia and Guillain-Barré syndrome in a renal transplant recipient.

作者信息

Maccario M, Tarantino A, Nobile-Orazio E, Ponticelli C

机构信息

Division of Nephrology and Dialysis, IRCCS Ospedale Maggiore, Milan, Italy.

出版信息

Transpl Int. 1998;11(6):439-42. doi: 10.1007/s001470050171.

Abstract

In patients who have not undergone transplantation, Guillain-Barré syndrome (GBS) is typically preceded by an acute infection often sustained by Campylobacter jejuni. Thus far, in renal transplant recipients, only eight cases of GBS have been reported. In seven patients GBS was attributed to cytomegalovirus infection and in the eighth patient to cyclosporin A neurotoxicity. We report here the case of a GBS in a renal transplant recipient following C. jejuni bacteremia. The infection quickly disappeared after erythromycin and methronidazole therapy. GBS progressively evolved into a paraparesis within 1 week. After reaching a plateau phase, the clinical status improved and the patient was able to walk unassisted after 3 weeks. At this last check-up, 54 months later, the patient was doing well with a functioning graft and only minimal weakness of the lower limbs.

摘要

在未接受移植的患者中,吉兰 - 巴雷综合征(GBS)通常在空肠弯曲菌引发的急性感染后出现。迄今为止,肾移植受者中仅报告了8例GBS。7例患者的GBS归因于巨细胞病毒感染,第8例患者的GBS归因于环孢素A神经毒性。我们在此报告1例肾移植受者在空肠弯曲菌菌血症后发生GBS的病例。经红霉素和甲硝唑治疗后,感染迅速消失。GBS在1周内逐渐发展为双下肢轻瘫。达到平台期后,临床状况改善,3周后患者能够独立行走。在54个月后的最后一次检查中,患者移植肾功能良好,仅下肢有轻微无力症状,情况良好。

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