Nguyen M V, Nicolas L, Gaudemer A
Laboratoire de Chimie de Coordination Bioorganique et Bioinorganique, ICMO URA CNRS 1384, Orsay, France.
Bioorg Med Chem Lett. 1998 Feb 3;8(3):227-32. doi: 10.1016/s0960-894x(97)10219-0.
Five new dihydroxamic acid ligands (L) (8, 10a, 10b, 10c and 13) have been synthesised and characterised as potential chelating agents for iron (Fe3+). The log stability constants of Fe2L3 and FeL+ from Fe3+ and L2- have been estimated to be log beta = 61.96 and log beta 1 = 22.8 respectively. The ability of these compounds to scavenge hydroxyl radicals (oOH) responsible for cell damage have been studied by esr spectroscopy.
已经合成并表征了五种新的异羟肟酸配体（L）（8、10a、10b、10c和13），作为铁（Fe3+）的潜在螯合剂。从Fe3+和L2-计算得到的Fe2L3和FeL+的对数稳定常数分别估计为logβ = 61.96和logβ1 = 22.8。通过电子自旋共振光谱研究了这些化合物清除导致细胞损伤的羟基自由基（·OH）的能力。
