Saito M, Mizuno T
Département de Biologie, Faculté des Sciences pharmaceutiques, Teikyo Université, Kanagawa-ken, Japon.
C R Seances Soc Biol Fil. 1998;192(5):1025-8.
We have investigated the induction of epidermal growth factor (EGF) in the urogenital sinus of fetal mice when the sinuses were cultured with testosterone. Immunofluorescence study revealed that almost no EGF is detectable in the pre-incubated sinuses, whereas EGF is induced in the sinus mesenchyme as early as 2 hours after the testosterone treatment. The results support the hypothesis that paracrine-like factors secreted from the sinus mesenchyme activated by androgens may be EGF or EGF-like growth factors that stimulate the sinus epithelium to induce prostatic buds.
我们研究了用睾酮培养胎鼠泌尿生殖窦时表皮生长因子（EGF）的诱导情况。免疫荧光研究显示，预培养的泌尿生殖窦中几乎检测不到EGF，而在睾酮处理后仅2小时，泌尿生殖窦间充质中就诱导产生了EGF。这些结果支持这样一种假说，即由雄激素激活的泌尿生殖窦间充质分泌的旁分泌样因子可能是刺激泌尿生殖窦上皮诱导前列腺芽形成的EGF或EGF样生长因子。
