Tsukamoto K, Furue M, Sato Y, Takayama O, Akasu R, Ohtake N, Wakamatsu K, Ito S, Tamaki K, Shimada S
Department of Dermatology, Yamanashi Medical University, Yamanashi, Japan.
Dermatology. 1998;197(4):338-42. doi: 10.1159/000018028.
Generalized melanosis occurs very rarely as a complication of malignant melanoma, and the pathogenesis of this condition is still unclear. Histological examination of pigmented skin and measurements of the DOPAquinone metabolites 5-S-cysteinyldopa (5-S-CD) and 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C) in the patient's serum and urine were carried out. Histological examination revealed basal hyperpigmentation, discrete melanoma cells and melanophages around the blood vessels and an unusual melanin deposition within collagen bundles in the dermis. The levels of 5-S-CD and 6H5MI2C were dramatically increased both in the patient's serum and urine. The deposition of DOPAquinone metabolites secreted by the melanoma cells may contribute to the unusual melanin deposition within collagen bundles in the affected dermis.
泛发性黑变病作为恶性黑色素瘤的一种并发症非常罕见，这种情况的发病机制仍不清楚。对患者的色素沉着皮肤进行了组织学检查，并测量了其血清和尿液中的多巴醌代谢产物5-S-半胱氨酰多巴（5-S-CD）和6-羟基-5-甲氧基吲哚-2-羧酸（6H5MI2C）。组织学检查显示基底色素沉着、离散的黑色素瘤细胞以及血管周围的噬黑素细胞，真皮内胶原束中有异常的黑色素沉积。患者血清和尿液中5-S-CD和6H5MI2C的水平均显著升高。黑色素瘤细胞分泌的多巴醌代谢产物的沉积可能导致受累真皮内胶原束中出现异常的黑色素沉积。
