2-烷氧基青霉烯类化合物的合成及其抗菌活性
Synthesis and antibacterial activity of 2-alkoxy penems.
作者信息
Afonso A, Hon F, Fett N, Weinstein J, Ganguly A K, Naples L, Hare R S, Miller G H
机构信息
Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.
出版信息
Bioorg Med Chem Lett. 1998 Oct 6;8(19):2793-6. doi: 10.1016/s0960-894x(98)00502-2.
PMID:9873624
Abstract
The phosphite mediated Oxalimide cyclization reaction was extended to 4-dithiocarbonates of N-oxalyl-2-azetidinones to synthesize 2-alkoxy penems 3. In general, the in vitro antibacterial potency of compounds 3 was weak compared to the highly potent 2-alkylthiopenems 2.
摘要
亚磷酸酯介导的草酰亚胺环化反应扩展至N-草酰基-2-氮杂环丁酮的4-二硫代碳酸酯，以合成2-烷氧基青霉烯3。一般而言，与高效的2-烷硫基青霉烯2相比，化合物3的体外抗菌效力较弱。
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