Pina Latorre M A, Cobeta J C, Rodilla F, Navarro N, Zabala S
Service of Neurology, Hospital Obispo Polanco, Teruel, Spain.
J Clin Pharm Ther. 1998 Oct;23(5):399-401. doi: 10.1046/j.1365-2710.1998.00172.x.
A number of drugs have been reported to cause neuromuscular blockade and/or to increase weakness in myasthenia gravis. We report on two patients, treated with felodipine and nifedipine for arterial hypertension, who presented with an exacerbation of their myasthenia gravis and a myasthenic syndrome or exacerbation of myasthenia gravis, respectively. The mechanism of action of calcium antagonist drugs at the neuromuscular junction is not yet well established, but it could be located at both presynaptic and postsynaptic levels.
据报道，一些药物可导致神经肌肉阻滞和/或加重重症肌无力患者的肌无力症状。我们报告了两名因动脉高血压接受非洛地平和硝苯地平治疗的患者，他们分别出现了重症肌无力加重和肌无力综合征或重症肌无力病情加重的情况。钙拮抗剂药物在神经肌肉接头处的作用机制尚未完全明确，但可能存在于突触前和突触后水平。
