口服半夏、干姜及其混合物对大鼠迷走神经胃支传出活动的影响。

Effect of oral administration of Pinellia ternata, Zingiberis rhizoma and their mixture on the efferent activity of the gastric branch of the vagus nerve in the rat.

作者信息

Niijima A, Kubo M, Hashimoto K, Komatsu Y, Maruno M, Okada M

机构信息

Niigata University School of Medicine, Department of Physiology, Japan.

出版信息

Neurosci Lett. 1998 Dec 11;258(1):5-8. doi: 10.1016/s0304-3940(98)00830-1.

DOI:10.1016/s0304-3940(98)00830-1

PMID:9876038

Abstract

The effect of taste stimulation of Pinellia temata, Zingiberis rhizoma and their mixture on the efferent activity of the gastric branch of the vagus nerve was observed in the anesthetized rat. Taste stimulation by Pinellia ternata (50 mg/ml, 10 min) resulted in a suppression in vagal gastric nerve activity. On the contrary, stimulation by Zingiberis rhizoma (50 mg/ml, 10 min) caused a facilitation in efferent activity. The mixture of Pinellia ternata and Zingiberis rhizoma (5:1, 50 mg/ml, 10 min stimulation) demonstrated no suppressive effect on gastric nerve activity. These observations indicate that it is reasonable to prescribe Pinellia ternata with Zingiberis rhizoma in traditional Japanese medicine to prevent suppressive effect of the taste of Pinellia ternata on gastric function.

摘要

在麻醉大鼠中观察了半夏、生姜及其混合物的味觉刺激对迷走神经胃支传出活动的影响。半夏（50mg/ml，10分钟）的味觉刺激导致迷走神经胃神经活动受到抑制。相反，生姜（50mg/ml，10分钟）的刺激使传出活动增强。半夏与生姜的混合物（5:1，50mg/ml，刺激10分钟）对胃神经活动无抑制作用。这些观察结果表明，在传统日本医学中，将半夏与生姜配伍使用以防止半夏味道对胃功能的抑制作用是合理的。