Periti P, Mazzei T
Department of Pharmacology, University of Florence, Italy.
J Chemother. 1998 Dec;10(6):427-48. doi: 10.1179/joc.1998.10.6.427.
This article reviews the new criteria for selecting the proper antimicrobial agent and dosage regimen for standard treatment of severe sepsis, with the intention of preventing septic shock. After introducing new concepts on the pathogenesis of sepsis and septic shock, the authors analyze the parameters of betalactam antibacterial activity, the antibiotic-induced release of bacterial endotoxin and the interrelationships between pharmacokinetics and pharmacodynamics of antibiotics in the search for an optimum dosage regimen of antimicrobial mono- or polytherapy for severely ill septic patients admitted to the intensive care unit.
本文综述了为预防感染性休克而选择合适抗菌药物及剂量方案用于严重脓毒症标准治疗的新准则。在介绍了脓毒症和感染性休克发病机制的新概念后，作者分析了β-内酰胺类抗菌活性参数、抗生素诱导的细菌内毒素释放以及抗生素药代动力学和药效学之间的相互关系，以探寻针对入住重症监护病房的重症脓毒症患者的抗菌单药治疗或联合治疗的最佳剂量方案。
