Jain R, Shah N H, Malick A W, Rhodes C T
Department of Applied Pharmaceutical Sciences, The University of Rhode Island, Kingston 02881, USA.
Drug Dev Ind Pharm. 1998 Aug;24(8):703-27. doi: 10.3109/03639049809082719.
There has been extensive research on drug delivery by biodegradable polymeric devices since bioresorbable surgical sutures entered the market two decades ago. Among the different classes of biodegradable polymers, the thermoplastic aliphatic poly(esters) such as poly(lactide) (PLA), poly(glycolide) (PGA), and especially the copolymer of lactide and glycolide referred to as poly(lactide-co-glycolide) (PLGA) have generated tremendous interest because of their excellent biocompatibility, biodegradability, and mechanical strength. They are easy to formulate into various devices for carrying a variety of drug classes such as vaccines, peptides, proteins, and micromolecules. Most importantly, they have been approved by the United States Food and Drug Administration (FDA) for drug delivery. This review presents different preparation techniques of various drug-loaded PLGA devices, with special emphasis on preparing microparticles. Certain issues about other related biodegradable polyesters are discussed.
自二十年前生物可吸收手术缝线进入市场以来，人们对可生物降解聚合物装置的药物递送进行了广泛研究。在不同种类的可生物降解聚合物中，热塑性脂肪族聚酯，如聚丙交酯（PLA）、聚乙交酯（PGA），尤其是丙交酯和乙交酯的共聚物聚（丙交酯-乙交酯）（PLGA），因其优异的生物相容性、生物降解性和机械强度而引起了极大关注。它们易于制成各种装置，用于承载多种药物类别，如疫苗、肽、蛋白质和小分子。最重要的是，它们已获得美国食品药品监督管理局（FDA）的药物递送批准。本综述介绍了各种载药PLGA装置的不同制备技术，特别强调了微粒的制备。还讨论了其他相关可生物降解聚酯的一些问题。
