哌甲酯对6-羟基多巴胺处理的新生大鼠的行为影响。
Behavioural effects of methylphenidate in 6-hydroxydopamine-treated neonatal rats.
作者信息
Eastgate S M, Wright J J, Werry J S
出版信息
Psychopharmacology (Berl). 1978 Jul 6;58(2):157-9. doi: 10.1007/BF00426899.
Neonatal rats treated at 7 days of age with 6-hydroxydopamine show normal levels of activity during maturation, but less hyperactivity than normals do when additionally treated with methylphenidate hydrochloride between 14 and 22 days of age. Comparison of these results with those of other workers suggests that several experimental variables must be controlled precisely if reproducible results analogous to the disturbed behaviour of children with minimal brain dysfunction (MBD) are to be obtained.
7日龄时用6-羟基多巴胺处理的新生大鼠在成熟过程中表现出正常的活动水平，但在14至22日龄期间额外用盐酸哌甲酯处理时，其多动程度低于正常大鼠。将这些结果与其他研究者的结果进行比较表明，如果要获得与轻度脑功能障碍（MBD）儿童的行为紊乱类似的可重复结果，必须精确控制几个实验变量。
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