Bourne L C, Rice-Evans C
International Antioxidant Research Centre, Guy's King's College, London, United Kingdom.
Biochem Biophys Res Commun. 1998 Dec 18;253(2):222-7. doi: 10.1006/bbrc.1998.9681.
There is a wealth of evidence for the powerful antioxidant properties in vitro of flavonoid components of the diet. However, few studies have been undertaken concerning the hydroxycinnamates, major constituents of fruit, some vegetables, beverages, and grains, particularly the extent to which they are absorbed in vivo from the diet. The study described here has investigated the bioavailability of ferulic acid in humans, from tomato consumption, through the monitoring of the pharmacokinetics of excretion in relation to intake. The results show that the peak time for maximal urinary excretion is approximately 7 h and the recovery of ferulic acid in the urine, on the basis of total free ferulic acid and feruloyl glucuronide excreted, is 11-25% of that ingested.
有大量证据表明饮食中的类黄酮成分在体外具有强大的抗氧化特性。然而，针对水果、某些蔬菜、饮料和谷物中的主要成分羟基肉桂酸，尤其是它们从饮食中被人体吸收的程度，所开展的研究却很少。本文所述的研究通过监测排泄的药代动力学与摄入量的关系，调查了人体食用番茄后阿魏酸的生物利用度。结果表明，最大尿排泄量的峰值时间约为7小时，基于排泄出的总游离阿魏酸和阿魏酰葡萄糖醛酸，尿液中阿魏酸的回收率为摄入剂量的11% - 25%。
