Hu S, Hager L P
Department of Biochemistry, University of Illinois, Urbana 61801, USA.
Biochem Biophys Res Commun. 1998 Dec 18;253(2):544-6. doi: 10.1006/bbrc.1998.9721.
This paper describes a new chloroperoxidase oxidative activity, namely, propargylic oxidations. Under appropriate conditions, chloroperoxidase catalyzes the oxidation of a variety of 2-alkynes to aldehydes via alcohol intermediates. Both hydrogen peroxide and t-butyl hydroperoxide can serve as terminal oxidants. The triple bond in the substrate is usually untouched. A free radical mechanism is proposed for the initial hydroxylation step in the overall reaction.
