Unusual propargylic oxidations catalyzed by chloroperoxidase.
作者信息
Hu S, Hager L P
机构信息
Department of Biochemistry, University of Illinois, Urbana 61801, USA.
出版信息
Biochem Biophys Res Commun. 1998 Dec 18;253(2):544-6. doi: 10.1006/bbrc.1998.9721.
PMID:9878571
Abstract
This paper describes a new chloroperoxidase oxidative activity, namely, propargylic oxidations. Under appropriate conditions, chloroperoxidase catalyzes the oxidation of a variety of 2-alkynes to aldehydes via alcohol intermediates. Both hydrogen peroxide and t-butyl hydroperoxide can serve as terminal oxidants. The triple bond in the substrate is usually untouched. A free radical mechanism is proposed for the initial hydroxylation step in the overall reaction.
摘要
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