Coletta R D, Almeida O P, Graner E, Page R C, Bozzo L
Discipline of Oral Pathology, Faculty of Odontology of Piracicaba-UNICAMP, São Paulo, Brazil.
J Periodontal Res. 1998 Nov;33(8):469-75. doi: 10.1111/j.1600-0765.1998.tb02346.x.
Hereditary gingival fibromatosis (HGF) is an oral condition characterized by the enlargement of the gingiva of both the maxilla and mandible. To study the cell proliferation index of fibroblasts from HGF and normal gingiva (NG), cell cultures from 4 members of the same family with HGF and from 4 healthy patients were established. Our results obtained from 6 different cell proliferation assays clearly showed that the cell proliferation rate was significantly higher in fibroblasts from HGF than from normal gingiva. HGF and control fibroblasts in subconfluent culture densities were typically spindle, but in saturation density HGF cells were shorter than control cells. These data suggest that the higher proliferative index of HGF fibroblasts possibly has a role in the pathogenesis of gingival outgrowth in HGF patients.
遗传性牙龈纤维瘤病（HGF）是一种口腔疾病，其特征为上颌和下颌牙龈均肿大。为研究HGF患者与正常牙龈（NG）成纤维细胞的细胞增殖指数，我们建立了来自同一家族4例HGF患者及4例健康对照者的细胞培养体系。我们通过6种不同的细胞增殖检测方法得出的结果清楚显示，HGF患者的成纤维细胞增殖速率显著高于正常牙龈的成纤维细胞。亚汇合培养密度下，HGF及对照成纤维细胞通常呈纺锤形，但在饱和密度下，HGF细胞比对照细胞短。这些数据表明，HGF成纤维细胞较高的增殖指数可能在HGF患者牙龈增生的发病机制中发挥作用。
