Sato S, Kitamura H, Mori M, Fukazawa M, Takeda M, Kadota K
Nansei Livestock Hygiene Service Center, Mie, Japan.
J Vet Med Sci. 1998 Dec;60(12):1349-51. doi: 10.1292/jvms.60.1349.
The histological and ultrastructural characteristics of an adenocarcinoma of the lung are described in an about 16-year-old female Steller sea lion with a 1.5 month history of cough and anorexia. The animal had multiple neoplastic nodules in the lungs and diaphragmatic pleura. The bronchial and mediastinal lymph nodes were replaced by neoplastic tissue, and there were several metastatic lesions in the liver and spleen. The lung tumor was characterized by accumulations of encapsulated lesions with central necrosis, and the neoplastic cells showing a papillary growth pattern produced small amounts of mucin. Ultrastructurally, some cells contained basal bodies, and cilia were rarely seen. This neoplasm was considered to be of ciliated bronchial or bronchiolar epithelium origin.
描述了一头约16岁雌性北海狗腺癌的组织学和超微结构特征，该海狗有1.5个月的咳嗽和厌食病史。该动物肺部和膈胸膜有多个肿瘤结节。支气管和纵隔淋巴结被肿瘤组织取代，肝脏和脾脏有多处转移灶。肺部肿瘤的特征是有包膜的病灶聚集并伴有中央坏死，呈乳头状生长模式的肿瘤细胞产生少量黏液。超微结构上，一些细胞含有基体，很少见到纤毛。该肿瘤被认为起源于纤毛支气管或细支气管上皮。
