Peirce J L, Derr R, Shendure J, Kolata T, Silver L M
Princeton University, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Mamm Genome. 1998 Dec;9(12):942-8. doi: 10.1007/s003359900904.
C57Bl/6 mice reproducibly prefer to ingest more 10% ethanol in a two-bottle choice paradigm than do DBA/2J mice. In this paper we report the identification of two new sex-specific alcohol preference (Alcp) loci. Melo and associates (1996) identified two loci: Alcp1, a male-specific locus on Chromosome (Chr) 2, and Alcp2, a female- and cross-specific locus on Chr 11. We have additionally identified Alcp3, a male-specific locus on Chr 3, and Alcp4, a female-specific locus on Chr 1. We have also performed a statistical analysis to exclude the possibility of undiscovered major alcohol preference loci that are not sex-specific in our backcross paradigm. Our results indicate that alcohol preference in C57BL/6 mice, as measured in our backcross, is largely controlled in a sex-specific manner.
在双瓶选择范式中，C57Bl/6小鼠相较于DBA/2J小鼠，可重复性地更倾向于摄取更多10%的乙醇。在本文中，我们报告了两个新的性别特异性酒精偏好（Alcp）位点的鉴定结果。Melo及其同事（1996年）鉴定出两个位点：Alcp1，位于第2号染色体上的雄性特异性位点；以及Alcp2，位于第11号染色体上的雌性和跨性别特异性位点。我们还鉴定出Alcp3，位于第3号染色体上的雄性特异性位点，以及Alcp4，位于第1号染色体上的雌性特异性位点。我们还进行了统计分析，以排除在我们的回交范式中未发现的非性别特异性主要酒精偏好位点的可能性。我们的结果表明，在我们的回交实验中所测量的C57BL/6小鼠的酒精偏好，在很大程度上是以性别特异性方式控制的。
