Ishiguro J
Department of Biology, Faculty of Science, Konan University, Kobe, Japan.
Genes Genet Syst. 1998 Aug;73(4):181-91. doi: 10.1266/ggs.73.181.
The fungal cell wall is an essential structure which protects cells from various environmental stresses such as hyper- or hypo-osmosis, and endows them with specific morphology in response to their life or cell division cycle. In addition, the cell wall has a variety of enzymatic activities per se, which are required for nutritional uptake, secretion, and cell adhesion including mating processes. In addition to these cytological interests, clinical demands to clarify the regulatory mechanisms of cell wall synthesis have been increasing, since the cell wall is a unique and effective target of antifungal agents. However, the molecular mechanisms are poorly understood at present, although the role of several signal transduction pathways have recently been implicated in regulation. In this review, the author focuses on genes and their interactions which are involved in fission yeast cell wall biogenesis.
真菌细胞壁是一种重要结构，可保护细胞免受各种环境压力，如高渗或低渗，使其在生命周期或细胞分裂周期中具有特定形态。此外，细胞壁本身具有多种酶活性，这些活性对于营养摄取、分泌以及包括交配过程在内的细胞黏附是必需的。除了这些细胞学方面的研究兴趣外，由于细胞壁是抗真菌药物的独特且有效的靶点，阐明细胞壁合成调控机制的临床需求也在不断增加。然而，尽管最近有研究表明几种信号转导途径参与了调控，但目前对其分子机制仍知之甚少。在这篇综述中，作者重点关注参与裂殖酵母细胞壁生物合成的基因及其相互作用。
